Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,951 – 1,965 of 5,523 results

1,951

Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG

Navitoclax (ABT-263) is a potent, orally active small-molecule inhibitor of anti-apoptotic Bcl-2 family proteins used in preclinical apoptosis and oncology research. Supplied as a powder, it is used for both in vitro assays and in vivo models, with documented solubility and recommended storage for stability.

Potent Bcl-2 family inhibitor for apoptosis research.
Orally active small molecule suitable for in vivo studies.
High solubility in DMSO for convenient stock solutions.
Available in multiple quantities for dosing flexibility.
Recommended storage conditions to preserve stability.

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1,952

Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and a potent antiviral drug primarily used in the treatment of human immunodeficiency virus (HIV) type 1 infection. It is effective against various strains of HIV-1, including those resistant to other NNRTI treatments. This product is intended for research use only.

Targets HIV-1 and HIV-2
Inhibits non-nucleoside reverse transcriptase
Effective against resistant HIV-1 strains
Suitable for research applications

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1,953

Medchemexpress LLC VK-II-86 | 955371-84-3 | 93.3% | 420.50 | 500 MG

VK-II-86 is a Carvedilol analogue that lacks antagonist activity at β-adrenoceptors in hypokalaemia. This compound effectively prevents hypokalaemia-induced ventricular arrhythmia through its multi-channel effects, counteracting all hypokalaemia-induced changes in ion channel activity and oxidative stress. For research use only.

Carvedilol analogue
Lacks antagonist activity at β-adrenoceptors
Prevents hypokalaemia-induced ventricular arrhythmia
Exhibits multi-channel effects
Counters hypokalaemia-induced changes in ion channel activity
Counters hypokalaemia-induced oxidative stress
Markedly reduces non-sustained and sustained ventricular tachyarrhythmias in a hypokalaemic murine whole-heart model

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1,954

Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG

SB 525334 is a selective small-molecule inhibitor of transforming growth factor-β receptor I (ALK5) used in preclinical research to block TGF-β signaling. It exhibits potent enzymatic inhibition and is supplied as a solid reagent for laboratory use.

selective ALK5 inhibitor with IC50 = 14.3 nM
high purity suitable for research use
molecular formula C21H21N5 and molecular weight 343.42 g/mol
available as a 200 MG solid pack for dosing flexibility
stable under recommended storage conditions when stored as directed

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1,955

Apexbio Technology LLC LY2784544 1229236-86-5 200mg

LY2784544 (CAS 1229236-86-5) is a potent and selective ATP-competitive inhibitor of JAK2 tyrosine kinase exhibiting an IC50 of 3 nM It demonstrates 8-fold and 16-fold selectivity over JAK1 and JAK3 respectively In cellular assays LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-TEL-JAK2 cells (IC50 0 191 nM) while displaying substantially reduced activity against JAK1 and JAK3-dependent STAT5 phosphorylation The compound suppresses proliferation and induces apoptosis in cells harboring the JAK2 V617F mutation In murine models it reduces tumor burden and strongly inhibits STAT5 phosphorylation in JAK2 V617F-driven cells LY2784544 is a valuable tool for studying JAK2-mediated signaling and myeloproliferative neoplasms

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1,956

TARGETMOL CHEMICALS INC ALACEPRIL 50MG

Also available in 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Alacepril (DU-1219) is a relatively novel angiotensin-converting enzyme inhibitor used as an antihypertensivepurity: 98%

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1,957

Apexbio Technology LLC Wnt agonist 1(Synonyms: Wnt Agonist I, Wnt signaling activator I, Wnt agonist compound 1, Wnt agonist-I), 200mg, CAS: 853220-52-7.

Wnt agonist 1 (CAS 853220-52-7) is a small-molecule stimulator of the canonical Wnt signaling pathway It functions by activating -catenin-dependent transcription mediated through the TCF transcription factor with an EC50 of approximately 0 7 M In Xenopus embryos treated from developmental stage 10 5 to stage 40 with Wnt agonist 1 (10 M) notable cephalic defects including reduced head size or absent eyes were observed mirroring phenotypes associated with increased Wnt signaling Researchers use Wnt agonist 1 to investigate Wnt pathway-regulated cellular differentiation and development

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1,958

eMolecules 552330-94-6 | 6-BROMO-3-QUINOLINOL | AstaTech | MFCD09260430 | 224.057 | C9H6BrNO | 95.000 | Oc1cnc2ccc(Br)cc2c1 | 5g | 213339936

6-BROMO-3-QUINOLINOL | AstaTech | 552330-94-6 | MFCD09260430 | 224.057 | C9H6BrNO | 95.000 | Oc1cnc2ccc(Br)cc2c1 | 5g | 213339936

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1,959

Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | MFCD00216696 | 99.89% | 161.16 | 500 G

8-Hydroxy-2(1H)-quinolinone is a biochemical reagent used in life science research. It is intended for research use only and not for medical applications.

Can be used as a biological material or organic compound
Suitable for life science related research
Available in solid form
White to off-white appearance

Pricing & Availability

1,960

Medchemexpress LLC Mivavotinib monohydrochloride | 1312691-33-0 | 344.39 | C17H21FN6O | 25 MG

Mivavotinib monohydrochloride is a research-grade small-molecule inhibitor of spleen tyrosine kinase (SYK) and fms-related tyrosine kinase 3 (FLT3), used to investigate kinase signaling and antitumor activity in preclinical studies. The compound is provided as a solid for formulation and assay use.

Potent dual SYK and FLT3 inhibition with low-nanomolar activity.
Suitable for biochemical and cell-based assays.
Useful as a tool compound in oncology and signal-transduction research.
Molecular formula C17H21FN6O and molecular weight 344.39 g/mol.

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1,961

Medchemexpress LLC Tamibarotene | 94497-51-5 | 99.57% | 351.44 | 200 MG

Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, demonstrating high selectivity over RARγ. It is intended for research use only.

Orally active retinoic acid receptor α (RARα) agonist
High selectivity over RARγ
Suitable for research use only

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1,962

Medchemexpress LLC Meconine | 569-31-3 | MFCD00219354 | 98.9% | 194.19 g/mol | C10H10O4 | 200 MG

Meconine is an endogenous metabolite of noscapine used as a research reagent and forensic marker for detecting illicit opiate use. It is supplied as a solid and as DMSO solutions for analytical and biological studies. CAS 569-31-3; molecular formula C10H10O4; molecular weight 194.19 g/mol.

High purity: 98.9% suitable for analytical applications.
Supplied as solid and 10 mM solutions in DMSO for ready use or reconstitution.
Useful as a biochemical marker to detect illicit opiate use in biological samples.
Available in small pack sizes (100 mg, 200 mg) and larger quantities on request.
Documentation includes a safety data sheet with handling and storage recommendations.

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1,963

AdipoGen Ethidium bromide Solution

Chemical. CAS 1239-45-8. Formula C21H20BrN3. MW 394.31. Synthetic. Ethidium bromide EtBr is the most commonly used nucleic acid stain for PAGE or agarose gel electrophoresis. The fluorescence of EtBr increases 21-fold upon binding to double-stranded RNA and 25-fold on binding double-stranded DNA so that destaining the background is not necessary with a low stain concentration 10 µg/ml. Ethidium bromide has been used in a number of fluorimetric assays for nucleic acids. Ethidium bromide intercalates double-stranded DNA and RNA and acts as a frameshift mutagen. It confers a deep red stain to DNA by acting as an intercalating agent between the starch bases. It has been shown to bind to single-stranded DNA although not as strongly and triple-stranded DNA. Because of its ability to bind to DNA, EtBr is an inhibitor of DNA polymerase. It can be used in conjunction with acridine orange to differentiate between viable, apoptotic and necrotic cells.

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1,964

Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 5 G

Dimidium bromide is a biochemical reagent suitable for use as a biological material or organic compound in life science-related research. It is intended for research use only and is not sold to patients.

Molecular weight: 380.28
Formula: C20H18BrN3
Appearance: Solid
Color: Pale purple to purple
Shipping: Room temperature in continental US; may vary elsewhere
Storage: RT, sealed storage, away from moisture and light. In solvent: -80°C for 1 year, -20°C for 6 months
Solubility (in vitro): DMSO : 125 mg/mL (328.71 mM; requires ultrasonic; hygroscopic DMSO significantly impacts solubility, use newly opened DMSO)

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1,965

eMolecules 362469-45-2 | (2-(Trifluoromethyl)quinolin-4-yl)methanol | Combi-Blocks | MFCD12197300 | 227.186 | C11H8F3NO | 96.000 | OCc1cc(nc2ccccc12)C(F)(F)F | 1g | 388720674

(2-(Trifluoromethyl)quinolin-4-yl)methanol | Combi-Blocks | 362469-45-2 | MFCD12197300 | 227.186 | C11H8F3NO | 96.000 | OCc1cc(nc2ccccc12)C(F)(F)F | 1g | 388720674

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Quinolines and derivatives

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Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Etravirine | 269055-15-4 | MFCD09837879 | 99.1% | C20H15BrN6O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC VK-II-86 | 955371-84-3 | 93.3% | 420.50 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2(1H)-Quinolinone, 8-hydroxy- | 15450-76-7 | MFCD00216696 | 99.89% | 161.16 | 500 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mivavotinib monohydrochloride | 1312691-33-0 | 344.39 | C17H21FN6O | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tamibarotene | 94497-51-5 | 99.57% | 351.44 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Meconine | 569-31-3 | MFCD00219354 | 98.9% | 194.19 g/mol | C10H10O4 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dimidium bromide | 518-67-2 | 98.6% | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More